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Carbon-14 was discovered on February 27, 1940, by Martin Kamen and Sam Ruben at the University of California Radiation Laboratory in Berkeley, California.

Its existence had been suggested by Franz Kurie in 1934. The primary natural source of carbon-14 on Earth is cosmic ray action on nitrogen in the atmosphere, and it is therefore a cosmogenic nuclide.

The fraction of the radiation transmitted through the dead skin layer is estimated to be 0.11.

Small amounts of carbon-14 are not easily detected by typical Geiger–Müller (G-M) detectors; it is estimated that G-M detectors will not normally detect contamination of less than about 100,000 disintegrations per minute (0.05 µCi).

This resemblance is used in chemical and biological research, in a technique called carbon labeling: carbon-14 atoms can be used to replace nonradioactive carbon, in order to trace chemical and biochemical reactions involving carbon atoms from any given organic compound.

These are relatively low energies; the maximum distance traveled is estimated to be 22 cm in air and 0.27 mm in body tissue.

Production rates vary because of changes to the cosmic ray flux caused by the heliospheric modulation (solar wind and solar magnetic field), and due to variations in the Earth's magnetic field.

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The different isotopes of carbon do not differ appreciably in their chemical properties.

Carbon dioxide also dissolves in water and thus permeates the oceans, but at a slower rate.